The Thebaid and the Reinterpretation of the Aeneid系统生物学
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内容提要：
enome sequences are now available that enable us to determine the biological components that make up a cell or an organism.The new discipline of systems biology examines how these components interact and form networks and how the net-works generate whole cell functions corresponding to observable phenotypes. This textbook, the first devoted to systems biology, describes how to model networks, how to determine their properties, and how to relate these to phenotypic functions. The prerequisite is some knowledge of linear algebra and biochemistry.Though the links between the mathematical ideas and biological processes are made clear, the book reflects the irreversible trend of increasing mathematical content in biology education.Therefore to assist both teacher and student, Palsson provides problem sets, proj-ects, and PowerPoint slides in an associated web site and keeps the presentation in the book concrete with illustrative material and experimental results.
作者简介：
Bernhard O.Palsson, Professor of Bioengineering and Adjunct Professor of Medicine, University of California, San Diego.
编辑推荐：
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Genome sequences are now available that enable us to determine the biological components that make up a cell or an organism. The new discipline of systems biology examines how these components interact and form networks, and how the networks generate whole cell functions corresponding to observable phenotypes. This textbook describes how to model networks, determine their properties, and relate these to phenotypic functions. Some knowledge of linear algebra and biochemistry is required, since the book reflects the irreversible trend of increasing mathematical content in biology education. 目录：
Preface
1 Introduction 2 Basic Concepts in Systems Biology PART I.RECONSTRUCTION OF BIOCHEMICAL NETWORKS 3 Metabolic Networks 4 Transcriptional Regulatory Networks PART II.MATHEMATICAL REPRESENTATION OF RECONSTRUCTED NETWORKS 5 Signaling Networks 6 Basic Features of the Stoichiometric Matrix 7 Topological Properties 8 Fundamental Subspaces of S 9 The (Right) Null Space of S 10 The Left Null Space of S 11 The Row and Column Spaces of S PART III CAPABILITIES OF RECONSTRUCTED NETORKS 12 Dual Causality 13 Properties of Solution Spaces 14 Sampling Solution Spaces 15 Finding Functional States 16 Parametric Sensitivity 17 Epilogue APPENDIX A.Nomenclature and Abbreviations APPENDIX B.E.coli Core Metabolic Network Bibliography Index |