Biology and Pathology of Trophoblast 胚胎滋养层生物学和病理学

This is the first dedicated, in-depth account of trophoblast: the tissue derived from the fertilized egg that nourishes and protects the developing fetus. The cells of the trophoblast have many unique qualities, and exhibit great variability across different species. It has a fascinating role in the development of the placenta and as a regulator during early growth of the embryo. These aspects are all fully covered as well as studies on why it is not rejected by the mother as 'foreign' tissue. This volume provides an up-to-date summary of the state of current knowledge and offers some glimpses as to future development on the scientific and clinical front.

James Cross, Tilo Kunath, P. Hajkova, S. E. Erhardt, M. A. Surani, Neil Brockdorff, R. A. Fisher, N. J. Sebire, Graham J. Burton, Eric Jauniaux, Olga Genbacev, Akraporn Prakobphol, Russell A. Foulk, Susan J. Fisher, E. B. Keverne, S. K. Dey, Susanne Tranguch, C. W. G. Redman, I. L. Sargent, E. A. Linton, Ashley Moffett, Charlie Loke

Chair’s introduction
Anne McLaren
1. Trophoblast cell fate specification
Discussion James Cross
2. Stem cells pluripotency and extraembryonic differentiation in the mouse Tilo Kunath
3. Epigenetic regulation of trophoblast development
P. Hajkova, S. E. Erhardt and M. A. Surani
4. Regulation of X chromosome inactivation in relation to lineage allocation in early mouse embryogenesis
Neil Brockdorff
5. Gestational Trophoblastic disease
R. A. Fisher and N. J. Sebire
6. Trophoblast and the first trimester environment
Graham J. Burton, Eric Jauniaux
7. Implantation is a sticky situation
Olga Genbacev, Akraporn Prakobphol, Russell A. Foulk and Susan J. Fisher
8. Trophoblast regulation of maternal endocrine function and behaviour
E. B. Keverne
9. Molecular signalling in embryo-uterine interactions during implantation
S. K. Dey and Susanne Tranguch
10.Trophoblast and pre-eclampsia
C. W. G. Redman, I. L. Sargent and E. A. Linton
11. Trophoblast and uterine mucosal leukocytes
Ashley Moffett
12. Immunology of trophoblast: a reappraisal
Y.W(Charlie)Loke.
Einal general eiscussion
Index