生物有机化学(第3版)(英文版)

The goal of bioorganic chemistry is to mimic biological processes such as enzyme action, through the synthesis of chemical models with the tools of the organic chemist. This widely-praised textbook is especially suited for the advanced undergraduate or graduate student in chemistry, biochemistry, medicinal chemistry, and pharmacology. The third edition has been substantially revised to reflect new research in the field, and features a major new chapter on self- assembly, auto-organization, and molecular devices. The outstanding figures continue to be a highlight of the book, and were described in an earlier edition as "accurate stereochemical structures...that are the best I've seen for showing the organic chemistry of biomolecules." (Quart. Rev. Biol.) --This text refers to the Paperback edition.
Discusses bioorganic chemistry designed to mimic biological processes such as enzyme action through the synthesis of chemical models with the tools of the organic chemist. Suited for advanced undergraduates or graduate students in chemistry and pharmacology. Softcover. DLC: Enzymes. --This text refers to the Paperback edition.

Series Preface
Preface to the Third Edition
Preface to the Second Edition
Preface to the First Edition
Chapter 1 Introduction to Bioorganic Chemistry
　1.1 Basic Cansiderations
　1.2 Proximity Effects in Organic Chemistry
　1.3 Molecular Adaptation
　1.4 Molecular Recognition and the Supramolecular Level
Chapter 2 Bioorganic Chemistry of Amino Acids and Polypeptides
2.1 Chemistry of the Living Cells
2.2 Analogy Betweel~ Organic Reactions and Biochemical Transformations
　2.3 Chemistry of the Peptide Bond
　2.4 Nonribosomal Peptide Bond Formation
　2.5 Asymmetric Synthesis of a-Amino Acids
　2.6 Asymmetric Synthesis with Chiral OrganometaUic Catalysts
　2.7 Transition State Analogs
　2.8 Antibodies as Enzymes
　2.10 Molecular Recognition and Drug Design
Chapter 3 Bioorganic Chemistry of the Phosphate Groups and Po[ynuc[eotides
3.1 Basic Considerations
3.2 Energy Storage
　3.3 Hydrolytic Pathways and Pseudorotation
3.4 DNA lntercalants
Chapter 4 Enzyme Chemistry
4.1 Introduction to Catalysis
4.2 Introduction to Enzymes
4.3 Multifunctional Catalysis and Simple Modeis
4.4 a-Chymotrypsin
4.5 Other Hydrolytic Enzymes
4.6 Stereoelectronic Control in Hydrolytic Reactions
4.7 Immobilized Enzymes and Enzyme Technology
4.8 Enzymes in Synthetic Organic Chemistry
4.9 Enzyme-Analog-Built Polymers
4.10 Design of Molecular Clefts
Chapter 5 Enzyme Models
5.1 Host Guest Complexation Chemistry
5.2 New Developments in Crown Ether Chemistry
5.3 Membrane Chenlistry and beliceIles
5.4 Polymers
5.5 CycIodextrins
5.6 Enzyme Design Using Steroid Template
5.7 Remote Functionalizadon Reactions
5.8 Biomimetic Polyene CycIizations
Chapter 6 Metar Ions
6.1 Metal Ions in Proteins and Biological MolecuIes
6.2 Carboxypeptidase A and the Role of Zinc
6.3 Hydrolysis of Amino Acid Esters and Amides and Peptides
6.4 Iron and Oxygen Transport
6.5 Copper Ion
6.6 Biomodels of Photosynthesis and Energy Transfer
6.7 Cobalt and Vitamin B,, Action
Chapter 7 Conenzyme Chemistry
Chapter 8 Molecular Devices
References
Index

It was over 100 years ago that Emil Fischer postulated his ingenious "lock-and-key" principle, which was subsequently applied to the development of a modern theory of enzyme catalysis. Later, the molecular recognition concept was used as the basis for the elaboration of the different fields of bioorganic chemistry. I am tempted to say that if Emil Fischer had lived in our time, he would undoubtedly be a leader in what is now called supramolecular chemistry, an important discipline of bioorganic chemistry. As we know, enzymes, by their comple..