临床内分泌学

List of contributors, ix
Foreword, xv
Preface to the second edition, xvii
Preface to the first edition, ixx
Part 1: Molecular Biology of
Endocrine Systems
1 Basic principles, 3 M. Vallejo and S.L. Lightman
2 Methods of investigation, 25 M. Hewison, J.A. Franklyn and M.C. Sheppard
3 Molecular aspects of hormonal regulation, 45 S.L. Chew
Part 2: Hormone Receptors and Intracellular Signalling
4 Hormone receptors and intracellular signalling, 57 S.P. Bide),, L.C. Best, D.W. Ray and J.R.E. Davis Part 3: Neuroendocrinology
5 Structure and function of the hypothalamus and pituitary, 83 A. C. Nieuwenhuijzen Kruseman
6 Regulation of the hypothalamus and pituitary, 90 J.S. Bevan and M.E Scanion
7 Measurement of circulating hormones, 113 R.J. Woods and P.J. Lowry
8 Hypothalamic and pituitary tumours: general principles, 129 M.E. Molitcb
9 Hyperprolactinaemia: causes, biochemical diagnosis and tests of prolactin secretion, 138 G. Delitala
10 Prolactinomas, 148 E Camanni and E. Ciccarelli
11 Galactorrhoea in women with normal basal prolactin concentrations, 164
P.S. Sharp and D.G. Jobnston 12 Acromegaly, 170 S. W.J. Lamberts
13 Functionless pituitary tumours, 184 G. Faglia and B. Ambrosi
14 Gonadotrophin-secreting pituitary adenomas, 192 S.L. Atkin and M.C. Wbite
15 Thyrotrophin-secreting pituitary tumours, 204 EE Casanueva, S.M. Webb and C. Dieguez
16 Isolated adrenocorticotrophic hormone deficiency, 216 S. Tsagarakis
17 Lymphocytic hypophysitis, 221 P.J. Jenkins
18 Craniopharyngiomas and other hypothalamic tumours, 225
P.N. Plowman, J. Girard, C. Irwin and D. Sebag-Montefiore
19 The surgery of hypothalamo-pituitary tumours, 242 C.B.T. Adams
20 Radiotherapy for pituitary tumours, 252 P.N. Plowman
21 Pituitary carcinoma and cytotoxic chemotherapy for aggressive pituitary tumours, 261 P.A. Price
22 Disorders of water balance, 265 P.H. Baylis
……

Conclusion
Endocrine systems and hormonal responses have been productive areas for molecular biologists. A complex and detailed view of the hormone response has been revealed.The major advances have been in understanding circadian clocks, macromolecule localisation and transport and the influence of RNA processing on gene expression.
References
1 Green MR. Biochemical mechanisms of constitutive and regulated pre-MRNA splicing. Ann Rev Cell Biol 1991; 7: 559-99.
2 Maniatis T. Mechanisms of alternative pre-mRNA splicing. Science1991; 251: 33-4.
3 Moore MJ, Query CC, Sharp PA. Splicing of precursors to MRNA by the spliceosome. In: Gesteland RF, Atkins JF, eds. The RNA World. New York: Cold Spring Harbor Laboratory Press, 1993: 303-57.
4 Wu JY, Maniatis T/Specific interactions between proteins implicated in splice site selection and regulated alternative splicing. Cell 1993; 75: 1061-70.
5 Amrein H, Hedley ML, Maniatis T. The role of specific protein-RNA and protein-protein interactions in positive and negative control of pre-mRNA splicing by Transformer 2. Cell 1994; 76:735--46.
6 Sun Q, Mayeda A, Hampson RK, Krainer A, Rottman FM. General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer. Genes Det, 1993; 7: 2598-608.
7 van Oers CCM, Adema GJ, Zandberg H, Moen TC, Baas PD. Two different sequence elements within exon 4 are necessary for calcitonin-specific splicing of the human calcitonin/calcitonin gene-related peptide I pre-mRNA. Mol Cell Biol 1994; 14: 951-60.
8 Del Gatto F, Breathnach R. Exon and intron sequences, respectively,repress and activate splicing of a fibroblast growth factor receptor 2 alternative exon. Mol Cell Biol 1995; 15: 4825-34.
9 Min H, Chan RC, Black DL. The generally expressed hnRNP F is involved in a neural-specific pre-mRNA splicing event. Genes Dev 1995; 9: 2659-71.
10 Caceres JF, Stamm S," Helfman DM, Krainer A. Regulation of alternative splicing ……